Adicción a la gabapentina / Gabapentin abuse

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[Multiple chemical sensitivity: study of 52 cases]. / Sensibilidad química múltiple: análisis de 52 casos.

BACKGROUND AND OBJECTIVE: Multiple chemical sensitivity (MCS) is characterized by a loss of tolerance to various environmental chemicals. The objective of this study was to describe patients with MCS seen in our hospital. PATIENTS AND METHOD: Patients consecutively seen by the Toxicology and Chronic Fatigue Units who presented symptoms of MCS were included. The diagnosis was clinical. All patients completed the Quick Environmental Exposure and Sensitivity Inventory (QEESI) questionnaire. RESULTS: Fifty-two patients were included. The average age (standard deviation) was 47.2 (7.6) years, and 46 (88%) were females. The origin of the syndrome was related to occupational exposure to various chemical agents in 31 cases (59.6%), including occupational accidents in 14 patients (fumigation of the workplace with insecticides). In 20 patients (38.5%), the syndrome could not be associated with any toxic exposure and was considered a manifestation of chronic fatigue syndrome. The QEESI showed mean scores of 72.9 (18.6) on the chemical inhalant intolerance scale, 45.5 (20.6) on the other intolerances scale, 69.8 (20.6) on the symptom severity scale, 4.4 (1.8) on the masking index and 66.6 (21.7) on the life impact scale. All patients were followed up for a minimum of 12 months, and during this period they remained stable with no deaths. CONCLUSIONS: MCS normally affects middle-aged women. It is frequently triggered by exposure to chemical agents, especially insecticides. An association with chronic fatigue syndrome is common. The prognosis is good but the patients' quality of life is seriously affected.

Sensibilidad química múltiple: análisis de 52 casos / Multiple chemical sensitivity: study of 52 cases

Fundamento y objetivo: La sensibilidad química múltiple (SQM) se caracteriza por la pérdida de tolerancia a la presencia en el medio ambiente de agentes químicos diversos. El objetivo de este trabajo es describir las características clínicas de una serie de pacientes con SQM atendidos en nuestro hospital. Pacientes y método: Se ha evaluado a los pacientes atendidos en las Unidades de Toxicología y de Fatiga Crónica que presentaban síntomas de SQM. El diagnóstico fue clínico. Todos ellos completaron el cuestionario QEESI (Quick Environmental Exposure and Sensitivity Inventory). Resultados: Se ha incluido a 52 pacientes, con una edad media (desviación estándar) de 47,2 (7,6) años; 46 eran mujeres (88%). El origen del síndrome pudo relacionarse con una exposición laboral a productos químicos en 31 pacientes (59,6%) y en 14 de ellos fue una fumigación con insecticidas en el lugar de trabajo. En 20 casos (38,5%) el síndrome no pudo relacionarse con ninguna exposición tóxica y constituía una manifestación más de un síndrome de fatiga crónica. En el cuestionario QEESI obtuvieron una media de 72,9 (18,6) puntos en la escala de exposición inhalatoria; 45,5 (20,6) en la de exposición no inhalatoria; 69,8 (20,6) en la de gravedad de los síntomas; 4,4 (1,8) en la de identificación de la exposición, y 66,6 (21,7) en la de repercusión sobre las actividades de la vida diaria. Todos los casos fueron controlados durante un mínimo de 12 meses, período durante el cual permanecieron estables y no se registró ningún fallecimiento. Conclusiones: La SQM incide habitualmente en mujeres de mediana edad. En general se desencadena por una exposición a productos químicos y muy en particular a insecticidas. La asociación con el síndrome de fatiga crónica es frecuente. El pronóstico vital es bueno, pero se reduce considerablemente la calidad de vida de los pacientes

Background and objective: Multiple chemical sensitivity (MCS) is characterized by a loss of tolerance to various environmental chemicals. The objective of this study was to describe patients with MCS seen in our hospital. Patients and method: Patients consecutively seen by the Toxicology and Chronic Fatigue Units who presented symptoms of MCS were included. The diagnosis was clinical. All patients completed the Quick Environmental Exposure and Sensitivity Inventory (QEESI) questionnaire. Results: Fifty-two patients were included. The average age (standard deviation) was 47.2 (7.6) years, and 46 (88%) were females. The origin of the syndrome was related to occupational exposure to various chemical agents in 31 cases (59.6%), including occupational accidents in 14 patients (fumigation of the workplace with insecticides). In 20 patients (38.5%), the syndrome could not be associated with any toxic exposure and was considered a manifestation of chronic fatigue syndrome. The QEESI showed mean scores of 72.9 (18.6) on the chemical inhalant intolerance scale, 45.5 (20.6) on the other intolerances scale, 69.8 (20.6) on the symptom severity scale, 4.4 (1.8) on the masking index and 66.6 (21.7) on the life impact scale. All patients were followed up for a minimum of 12 months, and during this period they remained stable with no deaths. Conclusions: MCS normally affects middle-aged women. It is frequently triggered by exposure to chemical agents, especially insecticides. An association with chronic fatigue syndrome is common. The prognosis is good but the patients' quality of life is seriously affected